微波促进下苯并咪唑与芳基卤化物的偶联反应 |
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引用本文: | 刘影英,陶兰,冯国仁. 微波促进下苯并咪唑与芳基卤化物的偶联反应[J]. 有机化学, 2008, 28(7): 1278-1281 |
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作者姓名: | 刘影英 陶兰 冯国仁 |
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作者单位: | 杭州师范大学材料与化学化工学院,杭州,310036 |
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基金项目: | 浙江省自然科学基金,浙江省有机化学重点学科建设 |
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摘 要: | 通过微波辐射, 苯并咪唑与多种卤素取代的芳基化合物在催化剂碘化亚铜、配体L-脯氨酸或N,N-二甲基甘氨酸的存在下, 以二甲基亚砜作溶剂, 在较低温度(75~110 ℃)下一步合成, 得到6种高产率的1-芳基取代苯并咪唑衍生物, 为该类化合物的合成提供了一种新方法. 产物通过熔点测定, 核磁共振氢谱、核磁共振碳谱、质谱等的表征.
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关 键 词: | 微波 苯并咪唑 芳基卤化物 偶联反应 |
收稿时间: | 2007-12-06 |
修稿时间: | 2008-01-25 |
Microwave-Enhanced Ullmann-Coupling Reaction of Benzimidazole with (Un)substituted Phenyl Halide |
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Affiliation: | (College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036) |
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Abstract: | The copper-catalyzed Ullmann-coupling reaction of benzimidazole with (un)substituted phenyl halide gave benzimidazole derivatives in good to excellent yields in DMSO at 75~110 ℃ under microwave irradiation conditions by using either L-proline or N,N-dimethylglycine as a ligand. This method provides a simple and inexpensive access to the title compounds. The structures of the products were confirmed by melting points, 1H NMR, 13C NMR and EI-MS spectra. |
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Keywords: | microwave benzimidazole (un)substituted phenyl halide Ullmann-coupling reaction |
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