Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols: An efficient access to homoallylic alcohols with a chiral quaternary center |
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Authors: | Qi Zhang Shou-Fei Zhu Yan Cai Li-Xin Wang Qi-Lin Zhou |
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Affiliation: | 1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, 300071, China
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Abstract: | Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed. A series of homoallylic alcohols with a chiral quaternary center were produced in high yields (up to 97%) and high enantioselectivities (up to 95% ee). The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center. |
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