Zinc-prolinamide complex catalyzed direct asymmetric aldol reactions in the presence of water |
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| Authors: | ZhiJin Lu HaiBo Mei GuangQian Zhang JianLin Han Yi Pan |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China
2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China
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| Abstract: | An efficient direct asymmetric aldol reaction with zinc triflate and prolinamides as combined catalysts is reported. A series of chiral prolinamides have been designed and used in the direct aldol reaction resulting in the desired products with excellent yields (up to 94% yield) and high enantioselectivities (up to 96% ee). Water was found to play a significant role in the formation of the aldol products, which suggests a new strategy in the design of new organic catalysts. |
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