One-pot synthesis of hyperbranched poly(amido amine) clicked with a sugar shell via Michael addition polymerization and thiol click reaction

This paper reports the production of glycopolymers via a simple and flexible method. A novel glycopolymer with a hyperbranched poly(amido amine) core and a sugar shell (HPAA-GLc) was synthesized by using thiol-ene click reaction via facile one-pot method. Hyperbranched poly(amido amine) with vinyl terminals was first synthesized by Michael addition polymerization of N,N′-methylene bisacrylamide (MBA) with 1-(2-aminoethyl) piperazine (AEPZ). Subsequently, thiol-ene click reaction between vinyl units of hyperbranched poly(amido amine) and thio-glucose was performed in situ. Based on the NMR result, all the vinyl groups reacted with thiol-glucose in 120 min. Strong photoluminescence emission was observed from the aqueous solution of HPAA-GLc.