Synthesis,X‐ray Diffraction Study,and Cytotoxicity of a Cationic p‐Cymene Ruthenium Chloro Complex Containing a Chelating Semicarbazone Ligand |
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| Authors: | Quan Zhou Peiyuan Li Rumei Lu Quanquan Qian Xiaolin Lei Qi Xiao Shan Huang Lifeng Liu Chusheng Huang Wei Su |
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| Institution: | 1. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530001, P. R. China;2. Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, Ministry of Education, Guangxi Teachers Education University, Nanning 530001, P. R. China;3. College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, P. R. China |
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| Abstract: | An organometallic salt composed of a new cationic p‐cymene ruthenium chloro complex containing a chelating benzaldehyde semicarbazone ligand and of the known anionic p‐cymene ruthenium trichloro complex, (η6‐p‐cymene)Ru(bzsc)Cl]+(η6‐p‐cymene)RuCl3]– ( 1 ) (bzsc = benzaldehyde semicarbazone) was synthesized and further characterized by IR, 1H NMR, and UV/Vis spectroscopy HR‐ESI mass spectrometry, and elemental analysis. The single‐crystal structure of 1 was also determined. The in vitro anticancer activities of the complex was evaluated against three human cancer cell lines (SGC‐7901, BEL‐7404 and CNE‐1), and the IC50 values were 20.7, 71.1 and 42.6 μM, respectively. |
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| Keywords: | Semicarbazones Ruthenium Cytotoxicity Antitumor agents |
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