Synthesis of 2-monofunctionalized 2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-diones |
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| Authors: | Kravchenko A N Maksareva E Yu Belyakov P A Sigachev A S Chegaev K Yu Lyssenko K A Lebedev O V Makhova N N |
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| Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation;(2) A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991 Moscow, Russian Federation |
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| Abstract: | New (1R*,5S*)-2-R-2,4,6,8-tetraazabicyclo3.3.0]octane-3,7-diones containing the terminal carboxy or hydroxy group in the substituent R were synthesized by cyclocondensation of 4,5-dihydroxyimidazolidin-2-one with 1-R-ureas. Single-crystal X-ray diffraction analysis showed that 2-carboxyethyl-2,4,6,8-tetraazabicyclo3.3.0]octane-3,7-dione crystallizes as a racemate. |
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| Keywords: | synthesis 2-monofunctionalized 2 4 6 8-tetraazabicyclo[3 3 0]octane-3 7-diones glycolurils carboxy- and hydroxyalkyl groups racemate X-ray diffraction analysis |
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