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| 比格犬自发疾病的病理组织学研究 | |
| 引用本文： | 朱奎成,刘娜,王纯耀,金树兴.比格犬自发疾病的病理组织学研究[J].实验动物科学,2011,28(2):76-77,80. |
| 作者姓名： | 朱奎成 刘娜 王纯耀 金树兴 |
| 作者单位： | 1. 郑州大学实验动物中心,郑州,450052;郑州大学药物安全性评价研究中心,郑州,450052 2. 郑州大学药物安全性评价研究中心,郑州,450052 3. 郑州大学实验动物中心,郑州,450052 |
| 摘 要： | 为了解比格犬组织器官的自发疾病，为药物的安全性评价提供背景资料，采用病理组织学方法对8～12月龄的36只比格犬主要脏器进行了观察，发现，肝脏、心脏、脾脏、肺脏、肾脏等组织器官均有不同程度的自发病变。 |
| 关 键 词： | 比格犬 自发病变 组织病理学 |
Histopathology of Spontaneous Lesions in Beagles Used for Toxicity Studies |
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| ZHU Kui-cheng,LIU Na,WANG Chun-yao,JIN Shu-xing.Histopathology of Spontaneous Lesions in Beagles Used for Toxicity Studies[J].Shiyan Dongwu Kexue,2011,28(2):76-77,80. | |
| Authors: | ZHU Kui-cheng LIU Na WANG Chun-yao JIN Shu-xing |
| Institution: | ZHU Kui-cheng1,LIU Na2,WANG Chun-yao1,JIN Shu-xing1(1.Laboratory Animal Center of Zhengzhou University,Zhengzhou 450052,China)(2.Drug Safety Evaluation and Research Center of Zhengzhou University,China) |
| Abstract: | A histopathological study was carried out on spontaneous lesions in 40 beagle dogs employed in toxicity studies.Lesions detected included acidophilic crystalline intraocular inclusion in the liver and kidney,atrophy and cyst formation in the thymus,siderofibrotic nodules in the spleen,and parafollicular cell hyperplasia in the thyroid.In addition,fatty and vacuolar degeneration,and nodular hyperplasia in the adrenal gland also be found |
| Keywords: | Beagle dogs Spontaneous lesions Histopathology |
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