Enantioselective total synthesis of bioactive natural product (+)-Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation |
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| Authors: | Mehta Goverdhan Shinde Harish M |
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| Affiliation: | Department of Organic Chemistry, Indian Institute of Science, Bangalore, India. gm@orgchem.iisc.ernet.in |
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| Abstract: | The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented. |
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