双嘧达莫在玻碳电极上的阳极伏安法研究

用直流伏安法(DCV),微分脉冲伏安法(DPV)和循环伏安法(CV)在玻碳电极(GCE)上研究了双嘧达莫(DPM)在不同介质中的阳极伏安行为,发现在0.01mol/LCHl溶液中于0.62V(vs.Ag/AgCl)右左生产一个阳极氧化峰,其峰高与浓度的线性方程分别为r=0.0004 0.17C(0.05~1.0mg/L)和y=0.052 0.22C(0.5~10mg/L). 在此体中大多数金属离子和20多种有机生代物质不干扰测定,采用该方法可不经分离,直接测定药物制剂和尿样吕DPM的含量,同时对DPM的电极反反应机理进行了探讨.

Anodic Voltammetry of Dipyridamole at a Glassy Carbon Electrode

The anodic voltammetric behavior of dipyridamole (DPM) in t hepresence of various electrolytes was studetd by direct-current voltammetry, di fferential-pulse voltammetry and cyclic voltammetry at a glassy carbon electrod e. In a medium of 0.01 mol/L HCl, an oxidative peak of dipyridamole was obtained . The peak potential is at about 0.62 V(vs.Ag/AgCl). The peak current is lin early increased with the concentration of dipyridamole over the range of 0.05～ 10 mg/L. The method has been used for the direct determination of dipyrida mole in tablets. The recoveries of dipyridamole in urine samples are 89%. Experi mental results proved that the electrode reaction was diffustion controlled and irreversible.