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Fabrication of the Components for a Sustained-Release Injectable Dosage Form of Acetylsalicylic Acid Using Supercritical Carbon Dioxide |
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| Authors: | E N Antonov S E Bogorodskii L I Krotova V K Popov V Yu Belov S V Kursakov V I Sevastyanov |
| Institution: | 1.Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics,Russian Academy of Sciences,Troitsk, Moscow,Russia;2.Institute of Medical and Biological Research and Technologies,Moscow,Russia;3.Shumakov Federal Research Center of Transplantology and Artificial Organs,Moscow,Russia |
| Abstract: | Fabrication of fine-grained (10–100 μm) bioresorbable powders of aliphatic polyesters containing therapeutically significant (up to 10 wt %) concentrations of acetylsalicylic acid using supercritical CO2 is studied. The process for fabricating the components of sustained-release injectable dosage forms of acetylsalicylic acid is elaborated. The kinetics of release of acetylsalicylic acid from polylactide microparticles into the normal saline solution in vitro is studied by high-performance liquid chromatography. |
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