| 头孢菌素类化合物的核磁共振谱研究 |
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| 引用本文： | 沙沂,张鹏,李宁,李文,王宇. 头孢菌素类化合物的核磁共振谱研究[J]. 波谱学杂志, 2007, 24(3): 347-352 |
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| 作者姓名： | 沙沂 张鹏 李宁 李文 王宇 |
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| 作者单位： | 沈阳药科大学 核磁共振实验室，辽宁 沈阳 110016 |
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| 摘 要： | 应用1H NMR、13C NMR和DEPT135°技术以及1H-1H COSY、HMBC、HMQC二维核磁共振技术，对头孢菌素类抗生素头孢替坦二钠、头孢曲松钠及头孢噻肟钠的质子信号和碳信号进行了全归属，并指出其核磁共振谱特征.
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| 关 键 词： | NMR 核磁共振技术 谱图归属 头孢替坦 头孢曲松 头孢噻肟
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| 文章编号： | 1000-4556（2007）03-0347-06 |
| 收稿时间： | 2006-11-21 |
| 修稿时间： | 2006-11-212007-01-17 |
An NMR Study on Cephalosporins |
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| SHA Yi,ZHANG Peng,LI Ning,LI Wen,WANG Yu. An NMR Study on Cephalosporins[J]. Chinese Journal of Magnetic Resonance, 2007, 24(3): 347-352 |
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| Authors: | SHA Yi ZHANG Peng LI Ning LI Wen WANG Yu |
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| Affiliation: | NMR Laboratory, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | In this study, 1H and 13C NMR spectra of three cephalosporins, cefotetan disodium, ceftriaxone and cefotaxime, were acquired and assigned. It was observed that the 13C NMR spectrum of cefotetan disodium showed evident signal splitting when DMSO-d6 was used as the solvent and such signal splitting was absent with D2O as the solvent. The results of variable temperature 13C NMR spectroscopy further demonstrated that the splitting of cefotetan disodium 13C signals was caused by that fact the compound has different conformations in DMSO-d6. |
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| Keywords: | NMR chemical shift assignment cefotetan disodium ceftriaxone cefotaxime |
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