Ternifolide A, a new diterpenoid possessing a rare macrolide motif from Isodon ternifolius |
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| Authors: | Zou Juan Du Xue Pang Guo Shi Yi-Ming Wang Wei-Guang Zhan Rui Kong Ling-Mei Li Xiao-Nian Li Yan Pu Jian-Xin Sun Han-Dong |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. |
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| Abstract: | Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being α-orientations in compound 1 were found for the first time. The absolute configurations of 1 and 3 were confirmed by X-ray diffraction study. Compounds 1 and 3 were evaluated for their cytotoxicity. |
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