A chemo-enzymatic cascade for the one-pot synthesis of 1-deoxy-d-xylulose 5-phosphate and 1-deoxy-d-xylulose |
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Authors: | Shao-Bo DaiJuan Liao Jie TianHeng Li Wen-Yun Gao |
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Institution: | Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education) and College of Life Sciences, Northwest University, 229 North Taibai Road, Xi’an, Shaanxi 710069, PR China |
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Abstract: | A chemo-enzymatic cascade for the one-pot preparation of 1-deoxy-d-xylulose 5-phosphate (DXP) and 1-deoxy-d-xylulose (DX) from stable, cheap, and easily available starting material R-glycidol is reported. The epoxide ring of R-glycidol was opened with phosphate to generate l-glycerol 3-phosphate, which was subsequently converted into the target molecules by combination of multi-enzymatic reactions in the same flask with purified overall yields of 27.6% (DXP) and 33% (DX), respectively. This approach represents the first one-pot chemo-enzymatic synthesis of these two biologically important compounds. |
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Keywords: | d-xylulose 5-phosphate" target="_blank">1-Deoxy-d-xylulose 5-phosphate d-xylulose" target="_blank">1-Deoxy-d-xylulose Chemo-enzymatic cascade Methylerythritol phosphate pathway |
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