Synthesis and antibacterial activity of new N-[2-(thiophen-3-yl)ethyl] piperazinyl quinolones |
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Authors: | Letafat Bahram Emami Saeed Mohammadhosseini Negar Faramarzi Mohammad Ali Samadi Nasrin Shafiee Abbas Foroumadi Alireza |
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Institution: | Department of Chemistry, Islamic Azad University, Central Tehran-Branch, Tehran, Iran. |
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Abstract: | As a part of continuing search for potential antibacterial agents in the quinolones field, we have synthesized novel quinolone agents bearing N-2-(thiophen-3-yl)ethyl] piperazinyl moiety in the 7-position of the quinolone ring. In vitro antibacterial evaluation of the target compounds showed that N-2-(thiophen-3-yl)ethyl] group attached to piperazine ring served as promising C-7 substituent for piperazinyl quinolone antibacterials. Among these derivatives, ciprofloxacin analogues, containing N-2-(thiophen-3-yl)-2-hydroxyiminoethyl] or N-2-(thiophen-3-yl)-2-methoxyiminoethyl] residue provided a high inhibition against all the tested Gram-positive organisms including methicillin-resistant Staphylococcus aureus comparable or superior with respect to the reference drugs norfloxacin and ciprofloxacin. |
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