COMPARISON OF THE PHOTOTOXICITY OF α-TERTHIENYL WITH THAT OF A SELENIUM AND OF AN OXYGEN ANALOGUE |
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| Authors: | F J Garcia E Yamamoto Z Abramowski K Downum G H N Towers |
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| Institution: | Botany Department, University of British Columbia, Vancouver, B. C. Canada V6T 1W5 |
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| Abstract: | Abstract— Two analogues of α-terthienyl, namely 2, 5di(2'-thienyl) selenophene and 2, 5di(2'-thienyl) furan have been prepared and their phototoxicities toward several microorganisms have been compared. Dose response studies with Escherichia coli indicate that α-terthienyl is more active than these analogues. α-Terthienyl was shown to be the most effective of the three compounds in the photoinactivation of yeast alcohol dehydrogenase. Diagnostic tests showed the participation of singlet oxygen in the photosensitization to different extents by these three thiophenes. |
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