Mechanochemical Strecker Reaction: Access to α‐Aminonitriles and Tetrahydroisoquinolines under Ball‐Milling Conditions |
| |
| Authors: | Dr José G Hernández Mathias Turberg Dr Ingo Schiffers Prof?Dr Carsten Bolm |
| |
| Institution: | 1. Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany;2. +49)?241‐8092‐391 |
| |
| Abstract: | A mechanochemical version of the Strecker reaction for the synthesis of α‐aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding α‐aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker‐type multicomponent reaction allowed the one‐pot synthesis of tetrahydroisoquinolines after a subsequent internal N‐alkylation reaction. |
| |
| Keywords: | ball milling mechanochemistry silica Strecker reaction tetrahydroisoquinolines |
|
