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Development of Axially Chiral Cyclo‐Biaryldiol Ligands with Adjustable Dihedral Angles |
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| Authors: | Pengxiang Zhang Dr Jipan Yu Fei Peng Xudong Wu Jiyang Jie Can Liu Hua Tian Dr Haijun Yang Prof Dr Hua Fu |
| Institution: | 1. http://chem.tsinghua.edu.cn;2. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, P.R. China |
| Abstract: | A new type of axially chiral cyclo‐1,1′‐biphenyl]‐2,2′‐diol (CYCNOL) ligands with adjustable dihedral angles have been developed by varying the bridge chain length. Eight‐, nine‐ and ten‐membered cyclo‐ligands were prepared and evaluated by using two representative examples: enantioselective additions of diethylzinc to aldehydes and organometallic reagents to enones. The results revealed that the fine regulation of dihedral angles through variation of the bridge chain length was effective in the asymmetric synthesis. |
| Keywords: | asymmetric catalysis asymmetric synthesis enantioselectivity ligand design ligand effects |