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Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch |
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| Authors: | Dr. Nuno Basílio Dr. Uwe Pischel |
| Affiliation: | 1. Laboratório Associado para a Química Verde (LAQV), Rede de Química e Tecnologia (REQUIMTE), Departmento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Caparica, Portugal;2. CIQSO - Center for Research in Sustainable Chemistry and, Department of Chemistry, University of Huelva, Campus de El Carmen s/n, Huelva, Spain |
| Abstract: | The reversibly switchable trans‐chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug‐cucurbit[7]uril host–guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction. |
| Keywords: | cucurbiturils drug delivery flavylium host– guest chemistry photochemistry |