Palladium‐Catalyzed N‐Arylation of Iminodibenzyls and Iminostilbenes with Aryl‐ and Heteroaryl Halides |
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Authors: | Dr Wenliang Huang Prof Stephen L Buchwald |
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Institution: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA), Fax: (+1) 617 253-3297 |
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Abstract: | Compounds containing the iminodibenzyl and iminostilbene ring systems are prevalent in medicinal targets and functional materials. Herein, we report palladium‐catalyzed conditions for the N‐arylation of these ring systems. This protocol could be applied to a variety of (hetero)aryl chloride and bromide substrates, including ones, which are sterically hindered or those containing a variety of functional groups. Use of the fourth‐generation palladacycle precatalyst gave good to excellent yields by using low palladium‐catalyst loadings (0.1 to 1 mol %). |
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Keywords: | amination imino compounds organic light emitting diodes (OLEDs) palladium synthetic methods |
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