Enantioselective Direct Alkynylation of Ketones Catalyzed by Chiral CCN Pincer RhIII Complexes |
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| Authors: | Dr Jun‐ichi Ito Shino Ubukata Shun Muraoka Prof?Dr Hisao Nishiyama |
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| Institution: | Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya, Japan |
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| Abstract: | A direct asymmetric alkynylation of ketones with new chiral CCN Rh catalysts containing N‐heterocyclic carbene and oxazoline hybrid ligands is described. The catalytic reaction of fluoroalkyl‐substituted ketones, ArCOCF2X (X=F, Cl, H), with aromatic and aliphatic alkynes yielded the corresponding chiral propargyl alcohols with high enantioselectivity. Control and kinetic experiments suggested a bis(alkynyl) Rh intermediate as the active species for the C?C bond‐forming step. |
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| Keywords: | alkynylation asymmetric synthesis ketones pincer ligands rhodium |
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