Product Control using Substrate Design: Ruthenium‐Catalysed Oxidative C−H Olefinations of Cyclic Weinreb Amides |
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| Authors: | Riki Das Dr. Manmohan Kapur |
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| Affiliation: | Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, India |
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| Abstract: | A new class of Weinreb amides has been developed as directing groups for the ruthenium‐catalysed regioselective oxidative C?H olefination. The new Weinreb amides successfully inhibit the N?O bond reductive cleavage usually associated with the cationic ruthenium system, thereby keeping intact the synthetic utility of Weinreb amides. Mechanistic studies reveal interesting aspects of the directing group capabilities of Weinreb amides when compared to simple amides of similar structures. |
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| Keywords: | C− H activation C− H functionalization oxidative-Heck ruthenium Weinreb amides |
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