Acidic Co‐Catalysts in Cationic Gold Catalysis |
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| Authors: | Dr. Pablo Barrio Manish Kumar Zhichao Lu Junbin Han Prof. Bo Xu Prof. Gerald B. Hammond |
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| Affiliation: | 1. Departamento de Química Orgánica, Universidad de Valencia., Burjassot, Spain;2. Department of Chemistry, University of Louisville, Louisville, Kentucky, USA;3. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P. R. China |
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| Abstract: | A systematic study on the effects of Lewis or Brønsted acid co‐catalysts in gold‐catalyzed reactions was undertaken using representative reactions (O‐, N‐, and C‐nucleophilic additions to alkynes). Through these reactions, it was demonstrated that an acidic co‐catalyst can increase the catalyst turnover significantly, enabling practical reaction rates at competitive catalyst loadings (<1 mol %). Further investigation is currently underway to improve the understanding of the subtle principles underlying these experimental observations. |
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| Keywords: | catalyst decay co-catalyst gold catalysis Lewis acid transition metal |
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