| Novel thermogelling poly(ε-caprolactone-co-lactide)-poly(ethylene glycol)-poly(ε-caprolactone-co-lactide) aqueous solutions |
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| 作者姓名： | Zhi Qiang Jiang Xian Mo Deng Jian Yuan Hao Chengdu Institute of Organic Chemistry Chinese Academy of Sciences P.O. Box Chengdu China Graduate School of Chinese Academy of Sciences Beijing China |
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| 作者单位： | Zhi Qiang Jiang，Xian Mo Deng，Jian Yuan Hao Chengdu Institute of Organic Chemistry，Chinese Academy of Sciences，P.O. Box 415，Chengdu 610041，China Graduate School of Chinese Academy of Sciences，Beijing 100039，China |
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| 基金项目： | This work was supported by the National Natural Sciences Foundation of China (No.50603025) and the Special Research Grant from the Dean of Chinese Academy of Sciences. |
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| 摘 要： | The aqueous solutions of poly(e-caprolactone-co-lactide)-poly(ethylene glycol)poly(e-caprolactone-co-lactide) undergoing sol-gel transition as the temperature increases from 20 to 50℃were successfully prepared. The thermogelling triblock copolymers were synthesized by subtle tuning of the chemical composition and the hydrophilicity/hydrophobicity balance. The sol-gel transition was studied focusing on structure-property relationship. The amphiphilic copolymer formed micelles in aqueous solutions. It is believed to have potential applications in drug delivery and tissue engineering.
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Novel thermogelling poly(?-caprolactone-co-lactide)–poly(ethylene glycol)–poly(?-caprolactone-co-lactide) aqueous solutions |
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| Zhi Qiang Jiang,Xian Mo Deng,Jian Yuan Hao Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,P.O. Box ,Chengdu ,China Graduate School of Chinese Academy of Sciences,Beijing ,China.Novel thermogelling poly(?-caprolactone-co-lactide)–poly(ethylene glycol)–poly(?-caprolactone-co-lactide) aqueous solutions[J].Chinese Chemical Letters,2007,18(6):747-749. |
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| Authors: | Zhi Qiang Jiang Xian Mo Deng Jian Yuan Hao |
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| Institution: | 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu 610041, China;2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | The aqueous solutions of poly(?-caprolactone-co-lactide)–poly(ethylene glycol)poly(?-caprolactone-co-lactide) undergoing sol–gel transition as the temperature increases from 20 to 50 °C were successfully prepared. The thermogelling triblock copolymers were synthesized by subtle tuning of the chemical composition and the hydrophilicity/hydrophobicity balance. The sol–gel transition was studied focusing on structure–property relationship. The amphiphilic copolymer formed micelles in aqueous solutions. It is believed to have potential applications in drug delivery and tissue engineering. |
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| Keywords: | Biomaterials Hydrogels Micelles Phase behavior |
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