通过自由基加成环化反应制备香豆素衍生物的研究进展

香豆素衍生物是一类重要的杂环内酯化合物,广泛应用于有机合成、生物医药及荧光材料等领域。开发新型简单高效的功能化香豆素合成策略一直受到人们的关注,通过苯丙炔酸酯与各类自由基前驱体的直接自由基加成环化反应为香豆素衍生物的功能化修饰提供了一条简单、清洁、高效的合成路线。本文综述了近年来基于自由基加成环化历程制备各类功能化香豆素衍生物的新进展。

Progress in the synthesis of coumarin derivatives through tandem radical addition/cyclization

Coumarin and its derivatives are a key class of heterocyclic lactone compounds, which are widely applied in organic synthesis, pharmaceutics, fluorescent materials, and so on. The development of a novel simple and efficient synthetic strategy of coumarins has been paid much attention. Recently, the tandem radical addition/cyclization of alkynoate with a radical precursor afforded a new, green and efficient method to the efficient synthesis of coumarins. In this review, the recent progress in the synthesis of coumarins through tandem radical addition/cyclization is summarized.