| 碱促进的喹啉酰胺类衍生物的绿色合成 |
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| 引用本文： | 马莲凤,李惠静,吴彦超.碱促进的喹啉酰胺类衍生物的绿色合成[J].化学通报,2019,82(6):516-521. |
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| 作者姓名： | 马莲凤 李惠静 吴彦超 |
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| 作者单位： | 哈尔滨工业大学(威海)海洋科学与技术学院 威海264209;哈尔滨工业大学(威海)海洋科学与技术学院 威海264209;哈尔滨工业大学(威海)海洋科学与技术学院 威海264209 |
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| 基金项目： | 国家自然科学基金项目（21672046, 21372054） |
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| 摘 要： | 从经济性和环保性考虑，本文以喹啉甲醛和芳香胺为原料，室温下利用廉价易处理的碱作为促进剂成功合成一系列喹啉酰胺衍生物，对所得产物进行了表征，考察了不同溶剂、碱和底物摩尔比对反应的影响，获得了优化的反应条件，并在文末提出了可能的反应机理。该反应具有条件温和、处理简单、收率较好、绿色环保等特点。
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| 关 键 词： | 室温 碱促进 酰胺化 喹啉酰胺 绿色环保 |
| 收稿时间： | 2018/12/7 0:00:00 |
| 修稿时间： | 2019/2/27 0:00:00 |
Base-Promoted Green Synthesis of Quinolinamide Derivatives |
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| Ma Lian-Feng,Li Hui-Jing and Wu Yan-Chao.Base-Promoted Green Synthesis of Quinolinamide Derivatives[J].Chemistry,2019,82(6):516-521. |
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| Authors: | Ma Lian-Feng Li Hui-Jing and Wu Yan-Chao |
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| Institution: | School of Marine science and technology,Harbin Institute of Technology,,School of Marine science and technology,Harbin Institute of Technology,School of Marine science and technology,Harbin Institute of Technology |
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| Abstract: | Based on the consideration of economy and environmental protection, a new method for the synthesis of a series of quinolinamide derivatives from quinolinecarboxaldehyde and aromatic amines has been developed by using an inexpensive and easy-to-handle base as the promoter at room temperature.The synthesized products were all characterized. The effects of solvents, bases and substrates molar ratios on the reaction were examined to obtain the optimal reaction conditions, and a possible reaction mechanism was proposed. The reaction possesses many advantages such as mild conditions, simple treatment, good yields, and environmental friendliness. |
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| Keywords: | Room Temperature Base-Promoted Amidation Quinolinamide Environmental-Friendly |
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