Synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with potential bioactivity in PEG-400 |
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| Authors: | Xi Cun Wang Xiao Mei Ding Sheng Qing Wang Xue Fei Chen Zheng Jun Quan |
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| Affiliation: | Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, China. Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China |
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| Abstract: | An environmental benign procedure for synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles has been developed by reaction of 2-amino-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with formic acid in PEG-400.The key advantages of this protocol are the shorter reaction time,higher yields,lower cost,simple workup,and environment-friendly compared to conventional organic solvent reaction.The present method does not involve any hazardous organic solvent or catalyst. |
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| Keywords: | 2-(N-Formyl)-5-atyl/aryloxymethyl-1,3,4-thiadiazoles 2-Amino-5-aryl/aryloxymethyl-l,3,4-thiadiazoles PEG-400 Synthesis |
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