Effect of substituent on the enantioselectivity for lipase-catalyzed kinetic resolution of glycerol derivatives |
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| Authors: | Yasuhiro Kawanami Akira Honnma Kayo Ohta Naoko Matsumoto |
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| Affiliation: | Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa 761-0795, Japan |
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| Abstract: | The lipase-catalyzed transesterifications of various substituted diphenyl 1,2-ketals of glycerol have been investigated. Efficient modification of the substrate structure with bis(4-bromophenyl) ketal was found to enhance the enantioselectivity up to E=57 at 0 °C. |
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| Keywords: | Lipase Transesterification Kinetic resolution Glycerol Substituent effect |
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