Synthesis of cis bis-β-lactams via Staudinger cycloaddition reaction using C2-symmetric 1,2-diamines |
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| Authors: | Aarif L Shaikh ARAS Deshmukh |
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| Institution: | a Division of Organic Chemistry (Synthesis) National Chemical Laboratory, Pune 411 008, India
b Center for Materials and Characterization, National Chemical Laboratory, Pune 411 008, India |
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| Abstract: | An efficient stereoselective synthesis of bis-β-lactams via cycloaddition reaction (Staudinger reaction) of ketenes with bisimines derived from C2-symmetric 1, 2-diamines is described. The reaction provided diastereomeric mixture of meso and C2-symmetric cis-bis-β-lactams with higher selectivity for meso-bis-β-lactams. |
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| Keywords: | Stereoselective synthesis Ketenes Imines Staudinger cycloaddition reaction |
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