Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues |
| |
| Authors: | Alison T Ung Stephen G Pyne Azlifa Sherif Anne SJ Lesage |
| |
| Institution: | a Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
b CNS Discovery Research, Johnson and Johnson Pharmaceutical Research and Development a Division of Janssen Pharmaceutica N.V., Beerse, B-2340, Belgium |
| |
| Abstract: | The conformationally restricted glutamate analogues, 4-aryl-1-amino-2-cyclopentene-1,3-dicarboxylates and their cyclopentane analogues have been prepared in a diastereoselective manner. Biological studies of 12a and 12b indicates that both compounds are modest antagonists at mGluR2. |
| |
| Keywords: | Metabotropic glutamate receptors Antagonists Heck reaction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
