Palladium-mediated approach to dibenzo[b,e][1,4]diazepines and benzopyrido-analogues. An efficient synthesis of tarpane |
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| Authors: | Egle M. Beccalli Gianluigi Broggini Caterina Zoni |
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| Affiliation: | a Istituto di Chimica Organica ‘A. Marchesini’, Facoltà di Farmacia, Università di Milano, via Venezian 21, 20133 Milano, Italy
b Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, via Valleggio 11, 22100 Como, Italy |
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| Abstract: | An original synthetic route toward dibenzo[b,e][1,4]diazepin-11-ones and analogues pyridobenzodiazepinones has been developed. The method relies upon an intramolecular amination process between an (hetero)aryl halide and the appropriate aniline moiety. |
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| Keywords: | Pd-catalyst Dibenzodiazepines Intramolecular cyclization Tarpane Buchwald-Hartwig amination |
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