Cyclodextrin assisted enantiomeric recognition of benzo[de]isoquinoline-1,3-dione derived amino acids

Spectroscopic evidence for enantiomeric recognition of properly modified amino acids through the cyclodextrin assisted formation of polymer like self-assemblies is presented. The requirements for the formation of these assemblies through aromatic π-π stacking are discussed. It is suggested that this approach can be used for enantiomeric separation of chiral compounds that contain both electron-rich and electron-poor moieties.