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2-Bromoethyl glycosides for synthesis of glycoconjugates on solid support
Authors:Ulf Ellervik  Mårten Jacobsson  Jörgen Ohlsson
Institution:Organic and Bioorganic Chemistry, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden
Abstract:2-Bromoethyl glycosides can easily and in high yields be transformed into sulfones by treatment with a suitable thiol followed by oxidation with mCPBA. The observation that the so formed sulfones were cleaved by treatment with NaOMe/MeOH was used to design a new safety catch linker for synthesis of glycoconjugates on solid support.
Keywords:Solid support  Glycoconjugates  Safety catch linker
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