The study of intramolecular tandem radical cyclizations of acylsilanes with radicalphiles attached on silicon |
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Authors: | Kuo-Hsiang Tang |
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Institution: | Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 106, Taiwan, ROC |
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Abstract: | Radical cyclizations of acylsilanes with radicalphilic pendant introduced on silicon proceeded in a tandem fashion to give spiro products containing a cyclic silyl ether skeleton. Because the alkoxysilyl group can be replaced with a hydroxy group through oxidation, the spiro silyl ethers can be converted into diols. In the case with a radical intermediate carrying 2-oxa-3-sila-6-heptenyl skeleton, products derived from 1,7-endo cyclization were obtained in good yields. |
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Keywords: | Acylsilanes Tandem radical cyclizations Alkoxysilane Brook rearrangement |
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