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New polychlorinated pyrrolidinones from the Red Sea marine sponge Lamellodysidea herbacea |
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| Authors: | Pierre Sauleau Jean Vacelet |
| Institution: | a Laboratoire de Chimie, UMR 5154 CNRS, Muséum National d'Histoire Naturelle, 63 rue Buffon, 75231 Paris Cedex 05, France b ICSN-CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France c Centre d'Océanologie de Marseille, Station Marine d' Endoume, rue de la Batterie des lions, Université de la Méditerranée-CNRS, F-13007 Marseille, France |
| Abstract: | Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of seven new polychlorinated derivatives 3-6 and 8-10 in addition to the known dysidamide 1, dysidamide B 2 and dysidamide C 7. Their structures were established by extensive NMR spectroscopic data. The absolute configuration of compound 9 was determined by X-ray crystallographic diffraction analysis. Dysidamide 1 exhibited neurotoxic effects towards both mesencephalic and cortical murine neurones at 0.8 μg/ml. |
| Keywords: | Lamellodysidea herbacea Sponge Dysidamide Polychlorinated pyrrolidinones |
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