Surface-functionalized silica-coated gold nanoparticles and their bioapplications |
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Authors: | Liu Shuhua Zhang Zhihua Wang Yubo Wang Fuke Han Ming-Yong |
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Affiliation: | Institute of Materials Research & Engineering and Division of Bioengineering, 3 Research Link, Singapore 117602, Singapore |
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Abstract: | Monodisperse Au at SiO2 nanoparticles has been functionalized with carboxylic groups for further bioconjugation with amino-terminated oligonucleotides. The oligonucleotide-modified Au at SiO2 nanoprobes have been applied in the fast colorimetric DNA based on the sequence-specific hybridization properties of DNA. Self-assembling behavior of Au at SiO2 nanoparticles was also investigated. |
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Keywords: | Gold nanoparticles Silica coating Surface functionalization Bioconjugation |
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