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Surface-functionalized silica-coated gold nanoparticles and their bioapplications
Authors:Liu Shuhua  Zhang Zhihua  Wang Yubo  Wang Fuke  Han Ming-Yong
Affiliation:Institute of Materials Research & Engineering and Division of Bioengineering, 3 Research Link, Singapore 117602, Singapore
Abstract:Monodisperse Au at SiO2 nanoparticles has been functionalized with carboxylic groups for further bioconjugation with amino-terminated oligonucleotides. The oligonucleotide-modified Au at SiO2 nanoprobes have been applied in the fast colorimetric DNA based on the sequence-specific hybridization properties of DNA. Self-assembling behavior of Au at SiO2 nanoparticles was also investigated.
Keywords:Gold nanoparticles   Silica coating   Surface functionalization   Bioconjugation
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