Development of resin-to-resin transfer reactions (RRTR) using Sonogashira chemistry |
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| Authors: | Judit Tulla-Puche |
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| Institution: | Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, MN 55455, USA |
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| Abstract: | Sonogashira chemistry can be used according to the ‘resin-to-resin transfer reaction’ (RRTR) concept. Two fragments, one containing the halide moiety and the second one incorporating the alkyne functionality, are anchored on different solid supports using allyl and/or Wang-type linkages. Treatment with Pd(0) cleaves the allyl-linked fragment(s) which subsequently undergo Sonogashira coupling under the same conditions. |
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| Keywords: | Solid-phase organic synthesis Resin-to-resin transfer reactions Sonogashira coupling |
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