|
|||||
|
|
Dibromomethane as one-carbon source in organic synthesis: total synthesis of (±)- and (−)-methylenolactocin |
|
| Authors: | Yung-Son Hon Cheng-Han Hsieh |
| Institution: | a Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 621, Taiwan, ROC b Institute of Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC |
| Abstract: | A general method was developed to construct monocyclic α-methylene-γ-butyrolactone moiety. The key step is to introduce the α-methylene group by the ozonolysis of mono-substituted alkenes followed by reacting with a preheated mixture of CH2Br2-Et2NH. Application of this key step in the total synthesis of the (±)- and (−)-methylenolactocin was described. |
| Keywords: | Ozonides α-Methylenation γ-Butyrolactone (&minus )-Methylenolactocin (± )-Methylenolactocin |
| 本文献已被 ScienceDirect 等数据库收录！ | |