Synthesis and lithiation of oxazolinylaziridines: the N-substituent effect |
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Authors: | Renzo Luisi Peppino Di Cunto Biagia Musio |
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Institution: | Dipartimento Farmaco-Chimico, Università di Bari, Via E.Orabona 4, I-70126-Bari, C.N.R., Istituto di Chimica dei Composti OrganoMetallici ‘ICCOM’, Sezione di Bari, Italy |
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Abstract: | The preparation of N-substituted oxazolinylaziridines and their deprotonation to afford the corresponding aziridinyllithiums is described. The chemical and configurational stability of the lithiated species depends on the N-substituent on the aziridine ring. The trapping with carbonyl compounds of (R*,S*) configurated oxazolinylaziridines is an interesting route for the preparation of functionalised α,β-aziridino-γ-lactones. |
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Keywords: | Aziridinyllithiums Oxazolinylaziridines Aziridino-γ-lactones Lithiation |
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