On the synthesis of pyrinodemin A. Part 1: The location of the olefin |
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| Authors: | Stuart P. Romeril Jack E. Baldwin Timothy D.W. Claridge |
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| Affiliation: | Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK |
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| Abstract: | The elucidation of the structure of the cytotoxic marine sponge alkaloid pyrinodemin A by synthesis is described. Based on the 13C NMR spectra of three double bond positional isomers and the natural product, it is concluded the C14′-C15′ isomer best represents the true structure of pyrinodemin A. In addition, the structural assignment of pyrinodemin C is evaluated. |
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| Keywords: | Sponge Pyrinodemin Alkaloids Nitrone EIMS |
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