Isocratic, simultaneous normal-phase LC separation of four impurities for a stavudine synthesis control |
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Authors: | Kazoka Helena Madre Marina |
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Institution: | Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, LV-1006 Riga, Latvia |
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Abstract: | The isocratic separation of impurities for a stavudine synthesis control has been studied by liquid chromatography (LC). The investigations have shown that isocratic reversed-phase LC conditions were unable to achieve a good separation. It was established that isocratic normal-phase LC system with common silica column as a stationary phase and the mixture of ethyl acetate with 4% (v/v) of ethylene glycol as a mobile phase is useful in simultaneous determination of four impurities for a stavudine synthesis control. |
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Keywords: | Stavudine Liquid chromatography Silica Mobile-phase composition |
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