Synthesis of α,α-disubstituted amino acids based on tandem reaction of dehydroamino acid derivatives |
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Authors: | Hideto Miyabe |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan |
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Abstract: | The formation of all-substituted sp3-hybridized carbon-center was investigated via tandem reaction of dehydroamino acid derivatives. The diethylzinc-promoted reaction of dehydroamino acid derivatives with acid anhydride or π-allyl palladium complex proceeded smoothly to afford α,α-disubstituted amino acids via a radical and anionic carbon-carbon bond-forming processes. The tandem reductive reaction of N-phthaloyl dehydroalanine also proceeded effectively by using Bu3SnH and Pd(PPh3)4. |
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Keywords: | Radical Palladium Tandem Dehydroamino acids Amino acids |
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