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A fragmentation-based method for the differentiation of glutathione conjugates by high-resolution mass spectrometry with electrospray ionization |
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| Authors: | Cen Xie Dafang ZhongXiaoyan Chen |
| Institution: | Center for Drug Metabolism and Pharmacokinetics Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
| Abstract: | |
| Keywords: | CE collision energy CID collision-induced dissociation ESI electrospray ionization FAB fast-atom bombardment GSH glutathione HLM s human liver microsomes LC-MS/MS liquid chromatography-tandem mass spectrometry NAC N-acetylcysteine NADPH β-nicotinamide adenine dinucleotide 2&prime -phosphate reduced tetrasodium salt UHPL C/Q-TOF MS ultra-high performance liquid chromatography-quadrupole-time of flight-mass spectrometry |
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