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Characterizing some gossypol and gossypolone Schiff's bases by studying their fragmentation patterns with electrospray ionization tandem mass spectra |
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| Authors: | Long Zhanga Xing Xin Caob Hai Xia Jiangb Biao Jiang Yu Xin Cui a State Key Laboratory of Natural Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China b |
| Institution: | Long Zhang~a,Xing Xin Cao~b,Hai Xia Jiang~b,Biao Jiang~(b,*),Yu Xin Cui~(a,*) a State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China b Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
| Abstract: | To investigate the structural form of gossypol and gossypolone Schiff's bases, seven relevant Schiff's bases were synthesized and the eleetrospray ionization-tandem mass spectrometry (ESI-MS/MS) with low-energy collision-induced dissociation was used to analyze their fragmentations. A common fragmentation pathway with the loss of RNH2 from those schiff's bases quasi-molecular ions was observed and proposed on the basis of their MS/MS spectra data. This common pathway indicated that those Schiff's bases existed mainly as the enamine form not the imine form previously showed in most reports. |
| Keywords: | Crossypol Schiff's bases Gossypolone Sehiff's bases ESI-MS Enamine form Imine form |
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