Biosynthesis of furanochromones in Pimpinella monoica |
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Authors: | D L Luthria and A Banerji |
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Institution: | (1) Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, 400085 Bombay, India |
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Abstract: | During a search for bioactive compounds from indigenous plants,Pimpinella monoica (Umbelliferae) was found to contain furocoumarin, isopimpenellin (3) and five biogenetically related furocoumarins viz khellin
(1), visnagin (2), visamminol (4), ammiol (5) and khellol (6). Labelled (i) and (2) were isolated from 1−14C]- and 2−14C]-acetates. Labelling pattern, determined by degradation of biosynthesised compounds, establishes the polyketide origin of
their aromatic and pyrone rings while the furan ring originates via an acetate-mevalonate pathway. The plant also utilises
glycine and leucine as substratevia acetate. Biotransformation of 3−3H]-visnagin to (6) but not to (2) was also observed. |
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Keywords: | Biosynthesis furochromones polyketide origin [3− 3H]-visnagin khellin |
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