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Synthesis of polysubstituted 4-fluoroquinolinones |
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| Authors: | Kiselyov Alexander S Piatnitski Evgueni L Doody Jacqueline |
| Institution: | Department of Chemistry, ImClone Systems, 180 Varick Street, 6th Floor, New York, New York 10014, USA. |
| Abstract: | reaction: see text] A convenient one-pot synthesis of 4-fluoroquinolinones that are active against KDR kinase is described. The mechanism of the reaction is believed to involve the formation of a quinone methide intermediate. |
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