Synthesis,Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2‐(Diphenylphosphanyl)ethylamine and Dithiocarbamates |
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| Authors: | Adam A A Sulaiman Muhammad Altaf Anvarhusein A Isab Abdullah Alawad Saleh Altuwaijri Saeed Ahmad |
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| Institution: | 1. Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia;2. Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia;3. National Center for Stem Cell Technology (NCSCT), Life Sciences and Environmental Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia;4. SAAD Research & Development Center, Clinical Research Lab., SAAD Specialist Hospital, Al‐Khobar, Saudi Arabia;5. Department of Chemistry, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Al‐Kharj, Saudi Arabia |
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| Abstract: | Gold(I) complexes of 2‐(diphenylphosphanyl)ethylamine or (2‐aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates (R2NCS2) were prepared by the reaction of these ligands with (CH3)2S‐AuCl in dichloromethane. The synthesized complexes Au(AEP)Cl] ( 1 ), Au(AEP)2]Cl ( 2 ), and Au2(R2NCS2)2]n (R2 = dimethyl ( 3 ), diethyl ( 4 ), and dibenzyl ( 5 )) were characterized by elemental analysis, IR, 1H, 13C and 31P NMR spectroscopy. The complexes were evaluated for anticancer activity against three cancer cells, A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines. Three of the five tested complexes showed significant in vitro cytotoxicity and for A549, the inhibition effect of three compounds is greater than cisplatin. |
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| Keywords: | Dithiocarbamate Gold Anticancer activities Spectroscopy |
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