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Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes |
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| Authors: | Swapna S Mohapatra Zoe E Wilson Sujit Roy Steven V Ley |
| Institution: | 1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK;2. Organometallics & Catalysis Laboratory, School of Basic Sciences, Indian Institute of Technology, Bhubaneswar 751013, India |
| Abstract: | Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation. |
| Keywords: | Alkylation Scandium triflate Bis(indolyl)methanes Flow Catalysis |
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