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Metal-free chemo- and regioselective acylation of pyridine derivatives with alcohols in water |
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| Authors: | Ebrahim Kianmehr Azin Pakbaznia Nasser Faghih Alireza Foroumadi |
| Affiliation: | 1. School of Chemistry, College of Science, University of Tehran, Tehran, 1417614411, Iran;2. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran |
| Abstract: | A straightforward acylaltion of pyridine derivatives has been developed using K2S2O8 as the oxidant and water as a green solvent. The corresponding 2-acylpyridines were synthesized with high chemo- and regioselectivity in good to high yields. This efficient and practical method could serve as a new tool for the convenient synthesis of 2-benzoylpyridines of interest for future pharmaceutical and chemical applications. |
| Keywords: | Metal-free Acylation Pyridine Alcohol Cross-coupling Green chemistry |
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