Synthesis of a novel sterically hindered chiral cyclic phosphoric acid derived from l-tartaric acid and application to the asymmetric catalytic Biginelli reaction |
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| Authors: | Xiaoyun Hu Rui Zhang Jinsheng Xie Zhongqiang Zhou Zixing Shan |
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| Affiliation: | 1. College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, China;2. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China |
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| Abstract: | A novel sterically hindered chiral cyclic phosphoric acid derived from l-tartaric acid was designed and synthesized based on highly regioselective cyclosulfitation of chiral 1,1,4,4-tetraphenylbutanetetraol. The asymmetric Biginelli reaction catalyzed by this newly synthesized chiral phosphoric acid was examined, and enantioselectivities up to 99% ee was obtained. |
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| Keywords: | Corresponding authors. |
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