A Parham Cyclization route to the 2,3-dihydro-1H-indazole-1,2-dicarboxylate ring systems via condensation of thermolabile aryllithium reagents and azodicarboxylate esters |
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| Authors: | John Farrokh Timothy Craven David A Hunt |
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| Institution: | Department of Chemistry, The College of New Jersey, 2000 Pennington Road, Ewing, NJ 08628, USA |
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| Abstract: | The Parham Cyclization reaction of o-lithiobenzyl chlorides (generated by low temperature halogen-metal exchange of the corresponding o-bromobenzyl chlorides with n-butyllithium) with azodicarboxylate esters provides a new entry to the 2,3-dihydro-1H-indazole-1,2-dicarboxylate ring system in moderate to good yield. |
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| Keywords: | Parham Cyclization Aryllithium reagents Azodicarboxylates Corresponding author |
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